Vezys Lab

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Robust Iterative Stimulation with Self-Antigens Overcomes CD8+ T Cell Tolerance to Self- and Tumor Antigens.

Nelson CE, Thompson EA, Quarnstrom CF, Fraser KA, Seelig DM, Bhela S, Burbach BJ, Masopust D, Vezys V. Cell Reports. 2019 Sep 17;28(12):3092-3104.e5. doi: 10.1016/j.celrep.2019.08.038.


Interstitial migration of CD8αβ T cells in the small intestine is dictated by environmental cues and quality of antigen experience.

Thompson EA, Mitchell JS, Beura LK, Torres D, Mrass P, Pierson MJ, Cannon JL, Masopust D, Fife BT, Vezys V. Cell Reports. 2019 Mar 12;26(11):2859-2867.e4. doi: 10.1016/j.celrep.2019.02.034.


Virus-specific memory T cells populate tumors and can be repurposed for tumor immunotherapy. 

Rosato PC, Wijeyesinghe S, Stolley JM, Nelson CE, Davis RL, Manlove LS, Pennell CA, Blazar BR, Chen CC, Geller MA, Vezys V, Masopust D. Nat Commun. 2019 Feb 4;10(1):567. doi: 10.1038/s41467-019-08534-1. PMID: 30718505


Reprogramming responsiveness to checkpoint blockade in dysfunctional CD8 T cells. 

Nelson CE, Mills LJ, McCurtain JL, Thompson EA, Seelig DM, Bhela S, Quarnstrom CF, Fife BT, Vezys V. Proc Natl Acad Sci U S A. 2019 Feb 12;116(7):2640-2645. doi: 10.1073/pnas.1810326116. Epub 2019 Jan 24. PMID: 30679280


Cutting Edge: Evidence for Nonvascular Route of Visceral Organ Immunosurveillance by T Cells. 

Steinert EM, Thompson EA, Beura LK, Adam OA, Mitchell JS, Guo M, Breed ER, Sjaastad FV, Vezys V, Masopust D. J Immunol. 2018 Jul 15;201(2):337-342. doi: 10.4049/jimmunol.1800279. Epub 2018 Jun 6. PMID: 29875151


T Cells in Nonlymphoid Tissues Give Rise to Lymph-Node-Resident Memory T Cells. 

Beura LK, Wijeyesinghe S, Thompson EA, Macchietto MG, Rosato PC, Pierson MJ, Schenkel JM, Mitchell JS, Vezys V, Fife BT, Shen S, Masopust D. Immunity. 2018 Feb 20;48(2):327-338.e5. doi: 10.1016/j.immuni.2018.01.015. PMID: 29466758


Intravital mucosal imaging of CD8+ resident memory T cells shows tissue-autonomous recall responses that amplify secondary memory. 

Beura LK, Mitchell JS, Thompson EA, Schenkel JM, Mohammed J, Wijeyesinghe S, Fonseca R, Burbach BJ, Hickman HD, Vezys V, Fife BT, Masopust D. Nat Immunol. 2018 Feb;19(2):173-182. doi: 10.1038/s41590-017-0029-3. Epub 2018 Jan 8. PMID: 29311694


Heterologous Vaccination and Checkpoint Blockade Synergize To Induce Antileukemia Immunity.

Manlove LS, Schenkel JM, Manlove KR, Pauken KE, Williams RT, Vezys V, Farrar MA. J Immunol. 2016 Jun 1;196(11):4793-804. doi: 10.4049/jimmunol.1600130. Epub 2016 Apr 25. PubMed PMID: 27183622; PubMed Central PMCID: PMC4875863.


Normalizing the environment recapitulates adult human immune traits in laboratory mice. 

Beura LK, Hamilton SE, Bi K, Schenkel JM, Odumade OA, Casey KA, Thompson EA, Fraser KA, Rosato PC, Filali-Mouhim A, Sekaly RP, Jenkins MK, Vezys V, Haining WN, Jameson SC, Masopust D. Nature. 2016 Apr 28;532(7600):512-6. doi: 10.1038/nature17655. Epub 2016 Apr 20. PubMed PMID: 27096360; PubMed Central PMCID: PMC4871315.


IL-15-Independent Maintenance of Tissue-Resident and Boosted Effector Memory CD8  T Cells.

Schenkel JM, Fraser KA, Casey KA, Beura LK, Pauken KE, Vezys V, Masopust D. J Immunol. 2016 May 1;196(9):3920-6. doi: 10.4049/jimmunol.1502337. Epub 2016 Mar 21. PubMed PMID: 27001957; PubMed Central PMCID: PMC5145194.


Shortened Intervals during Heterologous Boosting Preserve Memory CD8 T Cell Function but Compromise Longevity. 

Thompson EA, Beura LK, Nelson CE, Anderson KG, Vezys V. J Immunol. 2016 Apr 1;196(7):3054-63. doi: 10.4049/jimmunol.1501797. Epub 2016 Feb 22. PubMed PMID: 26903479; PubMed Central PMCID: PMC4799748.


Cutting edge: identification of autoreactive CD4+ and CD8+ T cell subsets resistant to PD-1 pathway blockade. 

Pauken KE, Nelson CE, Martinov T, Spanier JA, Heffernan JR, Sahli NL, Quarnstrom CF, Osum KC, Schenkel JM, Jenkins MK, Blazar BR, Vezys V, Fife BT. J Immunol. 2015 Apr 15;194(8):3551-3555. doi: 10.4049/jimmunol.1402262. Epub 2015 Mar 13. PubMed PMID: 25769925; PubMed Central PMCID: PMC4390507.


Lymphocytic choriomeningitis virus persistence promotes effector-like memory differentiation and enhances mucosal T cell distribution. 

Beura LK, Anderson KG, Schenkel JM, Locquiao JJ, Fraser KA, Vezys V, Pepper M, Masopust D. J Leukoc Biol. 2015 Feb;97(2):217-25. doi: 10.1189/jlb.1HI0314-154R. Epub 2014 Nov 13. PubMed PMID: 25395301; PubMed Central PMCID: PMC4304422.


Resident memory CD8 T cells trigger protective innate and adaptive immune responses. 

Schenkel JM, Fraser KA, Beura LK, Pauken KE, Vezys V, Masopust D. T cell memory. Science. 2014 Oct 3;346(6205):98-101. doi: 10.1126/science.1254536. Epub 2014 Aug 28. PubMed PMID: 25170049; PubMed Central PMCID: PMC4449618.


Cellular immune response against firefly luciferase after sleeping beauty-mediated gene transfer in vivo. 

Podetz-Pedersen KM, Vezys V, Somia NV, Russell SJ, McIvor RS. Hum Gene Ther. 2014 Nov;25(11):955-65. doi: 10.1089/hum.2014.048. Epub 2014 Sep 22. PubMed PMID: 25093708; PubMed Central PMCID: PMC4251089.


Cutting edge: generation of effector cells that localize to mucosal tissues and form resident memory CD8 T cells is controlled by mTOR. 

Sowell RT, Rogozinska M, Nelson CE, Vezys V, Marzo AL.J Immunol. 2014 Sep 1;193(5):2067-71. doi: 10.4049/jimmunol.1400074. Epub 2014 Jul 28. PubMed PMID: 25070853; PubMed Central PMCID: PMC4134982.


Pillars article: preferential localization of effector memory cells in nonlymphoid tissue. 

Masopust D, Vezys V, Marzo AL, Lefrançois L. Science. 2001. 291: 2413-2417. J Immunol. 2014 Feb 1;192(3):845-9. PubMed PMID: 24443507.


Intravascular staining for discrimination of vascular and tissue leukocytes. 

Anderson KG, Mayer-Barber K, Sung H, Beura L, James BR, Taylor JJ, Qunaj L, Griffith TS, Vezys V, Barber DL, Masopust D. Nat Protoc. 2014
Jan;9(1):209-22. doi: 10.1038/nprot.2014.005. Epub 2014 Jan 2. PubMed PMID: 24385150; PubMed Central PMCID: PMC4428344.


Preexisting high frequencies of memory CD8+ T cells favor rapid memory differentiation and preservation of proliferative potential upon boosting. 

Fraser KA, Schenkel JM, Jameson SC, Vezys V, Masopust D. Immunity. 2013 Jul 25;39(1):171-83. doi: 10.1016/j.immuni.2013.07.003. PubMed PMID: 23890070; PubMed Central PMCID: PMC3979587.


Sensing and alarm function of resident memory CD8 T cells. 

Schenkel JM, Fraser KA, Vezys V, Masopust D. Nat Immunol. 2013 May;14(5):509-13. doi: 10.1038/ni.2568. Epub 2013 Mar 31. Erratum in: Nat Immunol. 2013 Aug;14(8):876. PubMed PMID: 23542740; PubMed Central PMCID: PMC3631432.


Mucosal immunology: Infection induces friendly fire. 

Masopust D, Vezys V. Nature. 2012 Oct 4;490(7418):41-3. doi: 10.1038/490041a. PubMed PMID: 23038460.


Cutting edge: intravascular staining redefines lung CD8 T cell responses. 

Anderson KG, Sung H, Skon CN, Lefrancois L, Deisinger A, Vezys V, Masopust D. J Immunol. 2012 Sep 15;189(6):2702-6. doi: 10.4049/jimmunol.1201682. Epub 2012 Aug 15. PubMed PMID: 22896631; PubMed Central PMCID: PMC3436991.


Antigen-independent differentiation and maintenance of effector-like resident memory T cells in tissues. 

Casey KA, Fraser KA, Schenkel JM, Moran A, Abt MC, Beura LK, Lucas PJ, Artis D, Wherry EJ, Hogquist K, Vezys V, Masopust D. J Immunol. 2012 May 15;188(10):4866-75. doi: 10.4049/jimmunol.1200402. Epub 2012 Apr 13. PubMed PMID: 22504644; PubMed Central PMCID: PMC3345065.


Antigen-specific CD4 T-cell help rescues exhausted CD8 T cells during chronic viral infection.

Aubert RD, Kamphorst AO, Sarkar S, Vezys V, Ha SJ, Barber DL, Ye L, Sharpe AH, Freeman GJ, Ahmed R. Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):21182-7. doi: 10.1073/pnas.1118450109. Epub 2011 Dec 12. PubMed PMID: 
22160724; PubMed Central PMCID: PMC3248546.


4-1BB signaling synergizes with programmed death ligand 1 blockade to augment CD8 T cell responses during chronic viral infection. 

Vezys V, Penaloza-MacMaster P, Barber DL, Ha SJ, Konieczny B, Freeman GJ, Mittler RS, Ahmed R. J Immunol. 2011 Aug 15;187(4):1634-42. doi: 10.4049/jimmunol.1100077. Epub 2011 Jul 8. PubMed PMID: 21742975; PubMed Central PMCID: PMC4404506.


Dynamic T cell migration program provides resident memory within intestinal epithelium. 

Masopust D, Choo D, Vezys V, Wherry EJ, Duraiswamy J, Akondy R, Wang J, Casey KA, Barber DL, Kawamura KS, Fraser KA, Webby RJ, Brinkmann V, Butcher EC, Newell  KA, Ahmed R. J Exp Med. 2010 Mar 15;207(3):553-64. doi: 10.1084/jem.20090858. Epub 2010 Feb 15. PubMed PMID: 20156972; PubMed Central PMCID: PMC2839151.


Cytochrome c-induced lymphocyte death from the outside in: inhibition by serum leucine-rich alpha-2-glycoprotein-1. 

Codina R, Vanasse A, Kelekar A, Vezys V, Jemmerson R. Apoptosis. 2010 Feb;15(2):139-52. doi: 10.1007/s10495-009-0412-0. PubMed PMID: 19851871.


Memory CD8 T-cell compartment grows in size with immunological experience. 

Vezys V, Yates A, Casey KA, Lanier G, Ahmed R, Antia R, Masopust D. Nature. 2009 Jan 8;457(7226):196-9. doi: 10.1038/nature07486. Epub 2008 Nov 12. PubMed PMID: 19005468.


A brief history of CD8 T cells. 

Masopust D, Vezys V, Wherry EJ, Ahmed R. Eur  J Immunol. 2007 Nov;37 Suppl 1:S103-10. Review. PubMed PMID: 17972353.


Early virus-associated bystander events affect the fitness of the CD8 T cell response to persistent virus infection. 

Andrews NP, Pack CD, Vezys V, Barber GN, Lukacher AE. J Immunol. 2007 Jun 1;178(11):7267-75. PubMed PMID: 17513776.


Analysis of CD8+ T cell-mediated anti-viral responses in mice with targeted deletions of the M1 or M5 muscarinic cholinergic receptors. 

Vezys V, Masopust D, Desmarets M, Wess J, Zimring JC. Life Sci. 2007 May 30;80(24-25):2330-3. Epub 2007 Jan 13. PubMed PMID: 17286988; PubMed Central PMCID: PMC2034436.


Continuous recruitment of naive T cells contributes to heterogeneity of antiviral CD8 T cells during persistent infection. 

Vezys V, Masopust D, Kemball CC, Barber DL, O'Mara LA, Larsen CP, Pearson TC, Ahmed R, Lukacher AE. J Exp Med. 2006 Oct 2;203(10):2263-9. Epub 2006 Sep 11. PubMed PMID: 16966427; PubMed
Central PMCID: PMC2118117.


Stimulation history dictates memory CD8  T cell phenotype: implications for prime-boost vaccination. 

Masopust D, Ha SJ, Vezys V, Ahmed R. J Immunol. 2006 Jul 15;177(2):831-9. PubMed PMID: 16818737.


Cutting edge: gut microenvironment promotes differentiation of a unique memory CD8 T cell population.

Masopust D, Vezys V, Wherry EJ, Barber DL, Ahmed R. J Immunol. 2006 Feb 15;176(4):2079-83. PubMed PMID: 16455963.


A cytokine promoter/yellow fluorescent protein reporter transgene serves as an early activation marker of lymphocyte subsets. 

Kumar S, Skeen MJ, Adiri Y, Yoon H, Vezys VD, Lukacher AE, Evavold BD, Ziegler HK, Boss JM. Cell Immunol. 2005 Oct;237(2):131-40. Epub 2006 Jan 10. PubMed PMID: 16405934.


Late priming and variability of epitope-specific CD8+ T cell responses during a persistent virus infection. 

Kemball CC, Lee ED, Vezys V, Pearson TC, Larsen CP, Lukacher AE. J Immunol. 2005 Jun 15;174(12):7950-60. PubMed PMID: 15944301.


Fully functional memory CD8 T cells in the absence of CD4 T cells. 

Marzo AL, Vezys V, Klonowski KD, Lee SJ, Muralimohan G, Moore M, Tough DF, Lefrançois L. J Immunol. 2004 Jul 15;173(2):969-75. PubMed PMID: 15240684.


Activated primary and memory CD8 T cells migrate to nonlymphoid tissues regardless of site of activation or tissue of origin. 

Masopust D, Vezys V, Usherwood EJ, Cauley LS, Olson S, Marzo AL, Ward RL, Woodland DL, Lefrançois L. J Immunol. 2004 Apr 15;172(8):4875-82. PubMed PMID: 15067066.


Cutting edge: inflammatory signals drive organ-specific autoimmunity to normally cross-tolerizing endogenous antigen. 

Vezys V, Lefrançois L. J Immunol. 2002 Dec 15;169(12):6677-80. PubMed PMID: 12471097.


Tissue-level regulation of Th1 and Th2 primary and memory CD4 T cells in response to Listeria infection. 

Marzo AL, Vezys V, Williams K, Tough DF, Lefrançois. J Immunol. 2002 May 1;168(9):4504-10. PubMed PMID: 11970995.