Publications

CD4⁺ T cell memory

Künzli M, Masopust D. Nat Immunol. 2023;10.1038

Chronic antigen in solid tumors drives a distinct program of T cell residence

Gavil NV, Scott MC, Weyu E, Smith OC, O'Flanagan SD, Wijeyesinghe S, Lotfi-Emran S, Shiao SL, Vezys V, Masopust D. Chronic antigen in solid tumors drives a distinct program of T cell residence. Sci Immunol. 2023 Jun 8;8(84)

Depleting CD103+ resident memory T cells in vivo reveals immunostimulatory functions in oral mucosa.

Stolley JM, Scott MC, Joag V, Dale AJ, Johnston TS, Saavedra F, Gavil NV, Lotfi-Emran S, Soerens AG, Weyu E, Pierson MJ, Herzberg MC, Zhang N, Vezys V, Masopust D. J Exp Med. 2023;220(7)

Functional T cells are capable of supernumerary cell division and longevity

Soerens AG, Künzli M, Quarnstrom CF, Scott MC, Swanson L, Locquiao JJ, Ghoneim HE, Zehn D, Youngblood B, Vezys V, Masopust D.Nature. 2023;614(7949):762-766.

Tissue-resident memory T cells trigger rapid exudation and local antibody accumulation.

Rosato PC, Lotfi-Emran S, Joag V, Wijeyesinghe S, Quarnstrom CF, Degefu HN, Nedellec R, Schenkel JM, Beura LK, Hangartner L, Burton DR, Masopust D. Mucosal Immunol. 2023(1):17-26.

Route of self-amplifying mRNA vaccination modulates the establishment of pulmonary resident memory CD8 and CD4 T cells

Künzli M, O'Flanagan SD, LaRue M, Talukder P, Dileepan T, Stolley JM, Soerens AG, Quarnstrom CF, Wijeyesinghe S, Ye Y, McPartlan JS, Mitchell JS, Mandl CW, Vile R, Jenkins MK, Ahmed R, Vezys V, Chahal JS, Masopust D. Sci Immunol. 2022 ;7(78):eadd3075.

Novel Lymphocytic Choriomeningitis Virus Strain Sustains Abundant Exhausted Progenitor CD8 T Cells without Systemic Viremia

Beura LK, Scott MC, Pierson MJ, Joag V, Wijeyesinghe S, Semler MR, Quarnstrom CF, Busman-Sahay K, Estes JD, Hamilton SE, Vezys V, O'Connor DH, Masopust D. J Immunol. 2022;209(9):1691-1702

Functional virus-specific memory T cells survey glioblastoma.

Ning, J., Gavil, N. V., Wu, S., Wijeyesinghe, S., Weyu, E., Ma, J., Li, M., Grigore, F. N., Dhawan, S., Skorput, A. G. J., Musial, S. C., Chen, C. C., Masopust, D., & Rosato, P. C. Cancer immunology, immunotherapy.2022;CII, 71(8), 1863–1875.

Cutting Edge: Nucleocapsid Vaccine Elicits Spike-Independent SARS-CoV-2 Protective Immunity.

Matchett, W. E., Joag, V., Stolley, J. M., Shepherd, F. K., Quarnstrom, C. F., Mickelson, C. K., Wijeyesinghe, S., Soerens, A. G., Becker, S., Thiede, J. M., Weyu, E., O'Flanagan, S. D., Walter, J. A., Vu, M. N., Menachery, V. D., Bold, T. D., Vezys, V., Jenkins, M. K., Langlois, R. A., & Masopust, D. J Immunol. 2021;207(2):376-379.

Expansible residence decentralizes immune homeostasis

Wijeyesinghe, S., Beura, L. K., Pierson, M. J., Stolley, J. M., Adam, O. A., Ruscher, R., Steinert, E. M., Rosato, P. C., Vezys, V., & Masopust, D. Nature. 2021;592(7854):457-462.

Cutting Edge: Mouse SARS-CoV-2 Epitope Reveals Infection and Vaccine-Elicited CD8 T Cell Responses

Joag, V., Wijeyesinghe, S., Stolley, J. M., Quarnstrom, C. F., Dileepan, T., Soerens, A. G., Sangala, J. A., O'Flanagan, S. D., Gavil, N. V., Hong, S. W., Bhela, S., Gangadhara, S., Weyu, E., Matchett, W. E., Thiede, J., Krishna, V., Cheeran, M. C., Bold, T. D., Amara, R., Southern, P., … Masopust, D. J Immunol. 2021;206(5):931-935.

Retrograde migration supplies resident memory T cells to lung-draining LN after influenza infection.

Stolley, J. M., Johnston, T. S., Soerens, A. G., Beura, L. K., Rosato, P. C., Joag, V., Wijeyesinghe, S. P., Langlois, R. A., Osum, K. C., Mitchell, J. S., & Masopust, D. J Exp Med. 2020;217(8):e20192197.

Developmental plasticity allows outside-in immune responses by resident memory T cells

Fonseca, R., Beura, L. K., Quarnstrom, C. F., Ghoneim, H. E., Fan, Y., Zebley, C. C., Scott, M. C., Fares-Frederickson, N. J., Wijeyesinghe, S., Thompson, E. A., Borges da Silva, H., Vezys, V., Youngblood, B., & Masopust, D. Nat Immunol. 2020;21(4):412-421.

CD4 ⁺ resident memory T cells dominate immunosurveillance and orchestrate local recall responses

Beura, L. K., Fares-Frederickson, N. J., Steinert, E. M., Scott, M. C., Thompson, E. A., Fraser, K. A., Schenkel, J. M., Vezys, V., & Masopust, D. J Exp Med. 2019;216(5):1214-1229.

Virus-specific memory T cells populate tumors and can be repurposed for tumor immunotherapy

Rosato, P. C., Wijeyesinghe, S., Stolley, J. M., Nelson, C. E., Davis, R. L., Manlove, L. S., Pennell, C. A., Blazar, B. R., Chen, C. C., Geller, M. A., Vezys, V., & Masopust, D. Nat Commun. 2019;10(1):567.

Cutting Edge: Evidence for Nonvascular Route of Visceral Organ Immunosurveillance by T Cells

Steinert, E. M., Thompson, E. A., Beura, L. K., Adam, O. A., Mitchell, J. S., Guo, M., Breed, E. R., Sjaastad, F. V., Vezys, V., & Masopust, D. J Immunol. 2018;201(2):337-342.

T Cells in Nonlymphoid Tissues Give Rise to Lymph-Node-Resident Memory T Cells

Beura, L. K., Wijeyesinghe, S., Thompson, E. A., Macchietto, M. G., Rosato, P. C., Pierson, M. J., Schenkel, J. M., Mitchell, J. S., Vezys, V., Fife, B. T., Shen, S., & Masopust, D Immunity. 2018;48(2):327-338.e5.

Intravital mucosal imaging of CD8 ⁺ resident memory T cells shows tissue-autonomous recall responses that amplify secondary memory

Beura, L. K., Mitchell, J. S., Thompson, E. A., Schenkel, J. M., Mohammed, J., Wijeyesinghe, S., Fonseca, R., Burbach, B. J., Hickman, H. D., Vezys, V., Fife, B. T., & Masopust, D. Nat Immunol. 2018;19(2):173-182.

Normalizing the environment recapitulates adult human immune traits in laboratory mice

Beura, L. K., Hamilton, S. E., Bi, K., Schenkel, J. M., Odumade, O. A., Casey, K. A., Thompson, E. A., Fraser, K. A., Rosato, P. C., Filali-Mouhim, A., Sekaly, R. P., Jenkins, M. K., Vezys, V., Haining, W. N., Jameson, S. C., & Masopust, D. Nature. 2016;532(7600): 512-516.

IL-15-Independent Maintenance of Tissue-Resident and Boosted Effector Memory CD8 T Cells

Schenkel, J. M., Fraser, K. A., Casey, K. A., Beura, L. K., Pauken, K. E., Vezys, V., & Masopust, D. J Immunol. 2016;196(9): 3920-3926.

Quantifying Memory CD8 T Cells Reveals Regionalization of Immunosurveillance

Steinert, E. M., Schenkel, J. M., Fraser, K. A., Beura, L. K., Manlove, L. S., Igyártó, B. Z., Southern, P. J., & Masopust, D. Cell. 2015;161(4):737-749.

Lymphocytic choriomeningitis virus persistence promotes effector-like memory differentiation and enhances mucosal T cell distribution

Beura, L. K., Anderson, K. G., Schenkel, J. M., Locquiao, J. J., Fraser, K. A., Vezys, V., Pepper, M., & Masopust, D. J Leukoc Biol. 2015;97(2):217-225.

T cell memory. Resident memory CD8 T cells trigger protective innate and adaptive immune responses

Schenkel, J. M., Fraser, K. A., Beura, L. K., Pauken, K. E., Vezys, V., & Masopust, D. Science. 2014;346(6205):98-101.

Cutting edge: resident memory CD8 T cells occupy frontline niches in secondary lymphoid organs

Schenkel, J. M., Fraser, K. A., & Masopust, D. J Immunol. 2014;192(7):2961-2964.

Intravascular staining for discrimination of vascular and tissue leukocytes

Anderson, K. G., Mayer-Barber, K., Sung, H., Beura, L., James, B. R., Taylor, J. J., Qunaj, L., Griffith, T. S., Vezys, V., Barber, D. L., & Masopust, D. Nat Protoc. 2014;9(1):209-222.

Preexisting high frequencies of memory CD8+ T cells favor rapid memory differentiation and preservation of proliferative potential upon boosting

Fraser, K. A., Schenkel, J. M., Jameson, S. C., Vezys, V., & Masopust, D. Immunity. 2013;39(1):171-183.

Sensing and alarm function of resident memory CD8⁺ T cells

Schenkel, J. M., Fraser, K. A., Vezys, V., & Masopust, D. Nat Immunol. 2013;14(5):509-513.

Cutting edge: intravascular staining redefines lung CD8 T cell responses

Anderson, K. G., Sung, H., Skon, C. N., Lefrancois, L., Deisinger, A., Vezys, V., & Masopust, D. J Immunol. 2012;189(6):2702-2706.

Antigen-independent differentiation and maintenance of effector-like resident memory T cells in tissues

Casey, K. A., Fraser, K. A., Schenkel, J. M., Moran, A., Abt, M. C., Beura, L. K., Lucas, P. J., Artis, D., Wherry, E. J., Hogquist, K., Vezys, V., & Masopust, D. J Immunol. 2012;188(10):4866-4875.

Dynamic T cell migration program provides resident memory within intestinal epithelium

Masopust, D., Choo, D., Vezys, V., Wherry, E. J., Duraiswamy, J., Akondy, R., Wang, J., Casey, K. A., Barber, D. L., Kawamura, K. S., Fraser, K. A., Webby, R. J., Brinkmann, V., Butcher, E. C., Newell, K. A., & Ahmed, R. J Exp Med. 2010;207(3):553-564.

Activated primary and memory CD8 T cells migrate to nonlymphoid tissues regardless of site of activation or tissue of origin

Masopust, D., Vezys, V., Usherwood, E. J., Cauley, L. S., Olson, S., Marzo, A. L., Ward, R. L., Woodland, D. L., & Lefrançois, L. J Immunol. 2004;172(8):4875-4882.

PubMed Link