PubMed Link

Cutting Edge: First Lung Infection Permanently Enlarges Lymph Nodes and Enhances New T Cell Responses

Stolley JM, Scott MC, O'Flanagan SD, Künzli M, Matson CA, Weyu E, Langlois RA, Vezys V, Masopust D. J Immunol. 2024; 212(11):1621-1625.


CD4+ T cell memory 

Künzli M, Masopust D. Nat Immunol. 2023;10.1038


Chronic antigen in solid tumors drives a distinct program of T cell residence

Gavil NV, Scott MC, Weyu E, Smith OC, O'Flanagan SD, Wijeyesinghe S, Lotfi-Emran S, Shiao SL, Vezys V, Masopust D. Sci Immunol. 2023 Jun 8;8(84)


Depleting CD103+ resident memory T cells in vivo reveals immunostimulatory functions in oral mucosa.

Stolley JM, Scott MC, Joag V, Dale AJ, Johnston TS, Saavedra F, Gavil NV, Lotfi-Emran S, Soerens AG, Weyu E, Pierson MJ, Herzberg MC, Zhang N, Vezys V, Masopust D. J Exp Med. 2023;220(7)


Functional T cells are capable of supernumerary cell division and longevity

Soerens AG, Künzli M, Quarnstrom CF, Scott MC, Swanson L, Locquiao JJ, Ghoneim HE, Zehn D, Youngblood B, Vezys V, Masopust D.Nature. 2023;614(7949):762-766.


Tissue-resident memory T cells trigger rapid exudation and local antibody accumulation.

Rosato PC, Lotfi-Emran S, Joag V, Wijeyesinghe S, Quarnstrom CF, Degefu HN, Nedellec R, Schenkel JM, Beura LK, Hangartner L, Burton DR, Masopust D. Mucosal Immunol. 2023(1):17-26. 


Route of self-amplifying mRNA vaccination modulates the establishment of pulmonary resident memory CD8 and CD4 T cells

Künzli M, O'Flanagan SD, LaRue M, Talukder P, Dileepan T, Stolley JM, Soerens AG, Quarnstrom CF, Wijeyesinghe S, Ye Y, McPartlan JS, Mitchell JS, Mandl CW, Vile R, Jenkins MK, Ahmed R, Vezys V, Chahal JS, Masopust D. Sci Immunol. 2022 ;7(78):eadd3075. 


Novel Lymphocytic Choriomeningitis Virus Strain Sustains Abundant Exhausted Progenitor CD8 T Cells without Systemic Viremia

Beura LK, Scott MC, Pierson MJ, Joag V, Wijeyesinghe S, Semler MR, Quarnstrom CF, Busman-Sahay K, Estes JD, Hamilton SE, Vezys V, O'Connor DH, Masopust D. J Immunol. 2022;209(9):1691-1702


Functional virus-specific memory T cells survey glioblastoma. 

Ning, J., Gavil, N. V., Wu, S., Wijeyesinghe, S., Weyu, E., Ma, J., Li, M., Grigore, F. N., Dhawan, S., Skorput, A. G. J., Musial, S. C., Chen, C. C., Masopust, D., & Rosato, P. C. Cancer immunology, immunotherapy.2022;CII71(8), 1863–1875. 


Cutting Edge: Nucleocapsid Vaccine Elicits Spike-Independent SARS-CoV-2 Protective Immunity.

Matchett, W. E., Joag, V., Stolley, J. M., Shepherd, F. K., Quarnstrom, C. F., Mickelson, C. K., Wijeyesinghe, S., Soerens, A. G., Becker, S., Thiede, J. M., Weyu, E., O'Flanagan, S. D., Walter, J. A., Vu, M. N., Menachery, V. D., Bold, T. D., Vezys, V., Jenkins, M. K., Langlois, R. A., & Masopust, D. J Immunol. 2021;207(2):376-379.


Expansible residence decentralizes immune homeostasis

Wijeyesinghe, S., Beura, L. K., Pierson, M. J., Stolley, J. M., Adam, O. A., Ruscher, R., Steinert, E. M., Rosato, P. C., Vezys, V., & Masopust, D. Nature. 2021;592(7854):457-462.


Cutting Edge: Mouse SARS-CoV-2 Epitope Reveals Infection and Vaccine-Elicited CD8 T Cell Responses

Joag, V., Wijeyesinghe, S., Stolley, J. M., Quarnstrom, C. F., Dileepan, T., Soerens, A. G., Sangala, J. A., O'Flanagan, S. D., Gavil, N. V., Hong, S. W., Bhela, S., Gangadhara, S., Weyu, E., Matchett, W. E., Thiede, J., Krishna, V., Cheeran, M. C., Bold, T. D., Amara, R., Southern, P., … Masopust, D. J Immunol. 2021;206(5):931-935.


Retrograde migration supplies resident memory T cells to lung-draining LN after influenza infection. 

Stolley, J. M., Johnston, T. S., Soerens, A. G., Beura, L. K., Rosato, P. C., Joag, V., Wijeyesinghe, S. P., Langlois, R. A., Osum, K. C., Mitchell, J. S., & Masopust, D. J Exp Med. 2020;217(8):e20192197.


Developmental plasticity allows outside-in immune responses by resident memory T cells

Fonseca, R., Beura, L. K., Quarnstrom, C. F., Ghoneim, H. E., Fan, Y., Zebley, C. C., Scott, M. C., Fares-Frederickson, N. J., Wijeyesinghe, S., Thompson, E. A., Borges da Silva, H., Vezys, V., Youngblood, B., & Masopust, D. Nat Immunol. 2020;21(4):412-421.


CD4 + resident memory T cells dominate immunosurveillance and orchestrate local recall responses

Beura, L. K., Fares-Frederickson, N. J., Steinert, E. M., Scott, M. C., Thompson, E. A., Fraser, K. A., Schenkel, J. M., Vezys, V., & Masopust, D. J Exp Med. 2019;216(5):1214-1229.


Virus-specific memory T cells populate tumors and can be repurposed for tumor immunotherapy

Rosato, P. C., Wijeyesinghe, S., Stolley, J. M., Nelson, C. E., Davis, R. L., Manlove, L. S., Pennell, C. A., Blazar, B. R., Chen, C. C., Geller, M. A., Vezys, V., & Masopust, D. Nat Commun. 2019;10(1):567.


Cutting Edge: Evidence for Nonvascular Route of Visceral Organ Immunosurveillance by T Cells

Steinert, E. M., Thompson, E. A., Beura, L. K., Adam, O. A., Mitchell, J. S., Guo, M., Breed, E. R., Sjaastad, F. V., Vezys, V., & Masopust, D. J Immunol. 2018;201(2):337-342.


T Cells in Nonlymphoid Tissues Give Rise to Lymph-Node-Resident Memory T Cells

Beura, L. K., Wijeyesinghe, S., Thompson, E. A., Macchietto, M. G., Rosato, P. C., Pierson, M. J., Schenkel, J. M., Mitchell, J. S., Vezys, V., Fife, B. T., Shen, S., & Masopust, D Immunity. 2018;48(2):327-338.e5.


Intravital mucosal imaging of CD8 + resident memory T cells shows tissue-autonomous recall responses that amplify secondary memory

Beura, L. K., Mitchell, J. S., Thompson, E. A., Schenkel, J. M., Mohammed, J., Wijeyesinghe, S., Fonseca, R., Burbach, B. J., Hickman, H. D., Vezys, V., Fife, B. T., & Masopust, D. Nat Immunol. 2018;19(2):173-182.


Normalizing the environment recapitulates adult human immune traits in laboratory mice

Beura, L. K., Hamilton, S. E., Bi, K., Schenkel, J. M., Odumade, O. A., Casey, K. A., Thompson, E. A., Fraser, K. A., Rosato, P. C., Filali-Mouhim, A., Sekaly, R. P., Jenkins, M. K., Vezys, V., Haining, W. N., Jameson, S. C., & Masopust, D. Nature. 2016;532(7600): 512-516.


IL-15-Independent Maintenance of Tissue-Resident and Boosted Effector Memory CD8 T Cells

Schenkel, J. M., Fraser, K. A., Casey, K. A., Beura, L. K., Pauken, K. E., Vezys, V., & Masopust, D. J Immunol. 2016;196(9): 3920-3926.


Quantifying Memory CD8 T Cells Reveals Regionalization of Immunosurveillance

Steinert, E. M., Schenkel, J. M., Fraser, K. A., Beura, L. K., Manlove, L. S., Igyártó, B. Z., Southern, P. J., & Masopust, D. Cell. 2015;161(4):737-749.


Lymphocytic choriomeningitis virus persistence promotes effector-like memory differentiation and enhances mucosal T cell distribution

Beura, L. K., Anderson, K. G., Schenkel, J. M., Locquiao, J. J., Fraser, K. A., Vezys, V., Pepper, M., & Masopust, D. J Leukoc Biol. 2015;97(2):217-225.


T cell memory. Resident memory CD8 T cells trigger protective innate and adaptive immune responses 

Schenkel, J. M., Fraser, K. A., Beura, L. K., Pauken, K. E., Vezys, V., & Masopust, D. Science. 2014;346(6205):98-101.


Cutting edge: resident memory CD8 T cells occupy frontline niches in secondary lymphoid organs

Schenkel, J. M., Fraser, K. A., & Masopust, D. J Immunol. 2014;192(7):2961-2964.


Intravascular staining for discrimination of vascular and tissue leukocytes

Anderson, K. G., Mayer-Barber, K., Sung, H., Beura, L., James, B. R., Taylor, J. J., Qunaj, L., Griffith, T. S., Vezys, V., Barber, D. L., & Masopust, D. Nat Protoc. 2014;9(1):209-222.


Preexisting high frequencies of memory CD8+ T cells favor rapid memory differentiation and preservation of proliferative potential upon boosting

Fraser, K. A., Schenkel, J. M., Jameson, S. C., Vezys, V., & Masopust, D. Immunity. 2013;39(1):171-183.


Sensing and alarm function of resident memory CD8⁺ T cells

Schenkel, J. M., Fraser, K. A., Vezys, V., & Masopust, D. Nat Immunol. 2013;14(5):509-513.


Cutting edge: intravascular staining redefines lung CD8 T cell responses

Anderson, K. G., Sung, H., Skon, C. N., Lefrancois, L., Deisinger, A., Vezys, V., & Masopust, D.  J Immunol. 2012;189(6):2702-2706.


Antigen-independent differentiation and maintenance of effector-like resident memory T cells in tissues

Casey, K. A., Fraser, K. A., Schenkel, J. M., Moran, A., Abt, M. C., Beura, L. K., Lucas, P. J., Artis, D., Wherry, E. J., Hogquist, K., Vezys, V., & Masopust, D. J Immunol. 2012;188(10):4866-4875.


Dynamic T cell migration program provides resident memory within intestinal epithelium

 Masopust, D., Choo, D., Vezys, V., Wherry, E. J., Duraiswamy, J., Akondy, R., Wang, J., Casey, K. A., Barber, D. L., Kawamura, K. S., Fraser, K. A., Webby, R. J., Brinkmann, V., Butcher, E. C., Newell, K. A., & Ahmed, R.  J Exp Med. 2010;207(3):553-564. 


Memory CD8 T-cell compartment grows in size with immunological experience

Vezys, V., Yates, A., Casey, K. A., Lanier, G., Ahmed, R., Antia, R., & Masopust, D.  Nature. 2009;457(7226):196-199.


Stimulation history dictates memory CD8 T cell phenotype: implications for prime-boost vaccination

 Masopust, D., Ha, S. J., Vezys, V., & Ahmed, R. J Immunol. 2006;177(2):831-839.


Cutting edge: gut microenvironment promotes differentiation of a unique memory CD8 T cell population

Masopust, D., Vezys, V., Wherry, E. J., Barber, D. L., & Ahmed, R. J Immunol. 2006;176(4):2079-2083.


Activated primary and memory CD8 T cells migrate to nonlymphoid tissues regardless of site of activation or tissue of origin

Masopust, D., Vezys, V., Usherwood, E. J., Cauley, L. S., Olson, S., Marzo, A. L., Ward, R. L., Woodland, D. L., & Lefrançois, L. J Immunol. 2004;172(8):4875-4882.


Preferential localization of effector memory cells in nonlymphoid tissue

Masopust, D., Vezys, V., Marzo, A. L., & Lefrançois, L. Science. 2001;291(5512):2413-2417.


Direct analysis of the dynamics of the intestinal mucosa CD8 T cell response to systemic virus infection 

Masopust, D., Jiang, J., Shen, H., & Lefrançois, L.  J Immunol. 2001;166(4):2348-2356.


A critical role for CD40-CD40 ligand interactions in amplification of the mucosal CD8 T cell response

Lefrançois, L., Olson, S., & Masopust, D. J Exp Med. 1999;190(9):1275-1284.