PubMed Link
CD4+ T cell memory
Künzli M, Masopust D. Nat Immunol. 2023;10.1038
Depleting CD103+ resident memory T cells in vivo reveals immunostimulatory functions in oral mucosa.
Stolley JM, Scott MC, Joag V, Dale AJ, Johnston TS, Saavedra F, Gavil NV, Lotfi-Emran S, Soerens AG, Weyu E, Pierson MJ, Herzberg MC, Zhang N, Vezys V, Masopust D. J Exp Med. 2023;220(7)
Functional T cells are capable of supernumerary cell division and longevity
Soerens AG, Künzli M, Quarnstrom CF, Scott MC, Swanson L, Locquiao JJ, Ghoneim HE, Zehn D, Youngblood B, Vezys V, Masopust D.Nature. 2023;614(7949):762-766.
Tissue-resident memory T cells trigger rapid exudation and local antibody accumulation.
Rosato PC, Lotfi-Emran S, Joag V, Wijeyesinghe S, Quarnstrom CF, Degefu HN, Nedellec R, Schenkel JM, Beura LK, Hangartner L, Burton DR, Masopust D. Mucosal Immunol. 2023(1):17-26.
Route of self-amplifying mRNA vaccination modulates the establishment of pulmonary resident memory CD8 and CD4 T cells
Künzli M, O'Flanagan SD, LaRue M, Talukder P, Dileepan T, Stolley JM, Soerens AG, Quarnstrom CF, Wijeyesinghe S, Ye Y, McPartlan JS, Mitchell JS, Mandl CW, Vile R, Jenkins MK, Ahmed R, Vezys V, Chahal JS, Masopust D. Sci Immunol. 2022 ;7(78):eadd3075.
Novel Lymphocytic Choriomeningitis Virus Strain Sustains Abundant Exhausted Progenitor CD8 T Cells without Systemic Viremia
Beura LK, Scott MC, Pierson MJ, Joag V, Wijeyesinghe S, Semler MR, Quarnstrom CF, Busman-Sahay K, Estes JD, Hamilton SE, Vezys V, O'Connor DH, Masopust D. J Immunol. 2022;209(9):1691-1702
Functional virus-specific memory T cells survey glioblastoma.
Ning, J., Gavil, N. V., Wu, S., Wijeyesinghe, S., Weyu, E., Ma, J., Li, M., Grigore, F. N., Dhawan, S., Skorput, A. G. J., Musial, S. C., Chen, C. C., Masopust, D., & Rosato, P. C. Cancer immunology, immunotherapy.2022;CII, 71(8), 1863–1875.
Cutting Edge: Nucleocapsid Vaccine Elicits Spike-Independent SARS-CoV-2 Protective Immunity.
Matchett, W. E., Joag, V., Stolley, J. M., Shepherd, F. K., Quarnstrom, C. F., Mickelson, C. K., Wijeyesinghe, S., Soerens, A. G., Becker, S., Thiede, J. M., Weyu, E., O'Flanagan, S. D., Walter, J. A., Vu, M. N., Menachery, V. D., Bold, T. D., Vezys, V., Jenkins, M. K., Langlois, R. A., & Masopust, D. J Immunol. 2021;207(2):376-379.
Expansible residence decentralizes immune homeostasis
Wijeyesinghe, S., Beura, L. K., Pierson, M. J., Stolley, J. M., Adam, O. A., Ruscher, R., Steinert, E. M., Rosato, P. C., Vezys, V., & Masopust, D. Nature. 2021;592(7854):457-462.
Cutting Edge: Mouse SARS-CoV-2 Epitope Reveals Infection and Vaccine-Elicited CD8 T Cell Responses
Joag, V., Wijeyesinghe, S., Stolley, J. M., Quarnstrom, C. F., Dileepan, T., Soerens, A. G., Sangala, J. A., O'Flanagan, S. D., Gavil, N. V., Hong, S. W., Bhela, S., Gangadhara, S., Weyu, E., Matchett, W. E., Thiede, J., Krishna, V., Cheeran, M. C., Bold, T. D., Amara, R., Southern, P., … Masopust, D. J Immunol. 2021;206(5):931-935.
Retrograde migration supplies resident memory T cells to lung-draining LN after influenza infection.
Stolley, J. M., Johnston, T. S., Soerens, A. G., Beura, L. K., Rosato, P. C., Joag, V., Wijeyesinghe, S. P., Langlois, R. A., Osum, K. C., Mitchell, J. S., & Masopust, D. J Exp Med. 2020;217(8):e20192197.
Developmental plasticity allows outside-in immune responses by resident memory T cells
Fonseca, R., Beura, L. K., Quarnstrom, C. F., Ghoneim, H. E., Fan, Y., Zebley, C. C., Scott, M. C., Fares-Frederickson, N. J., Wijeyesinghe, S., Thompson, E. A., Borges da Silva, H., Vezys, V., Youngblood, B., & Masopust, D. Nat Immunol. 2020;21(4):412-421.
CD4 + resident memory T cells dominate immunosurveillance and orchestrate local recall responses
Beura, L. K., Fares-Frederickson, N. J., Steinert, E. M., Scott, M. C., Thompson, E. A., Fraser, K. A., Schenkel, J. M., Vezys, V., & Masopust, D. J Exp Med. 2019;216(5):1214-1229.
Virus-specific memory T cells populate tumors and can be repurposed for tumor immunotherapy
Rosato, P. C., Wijeyesinghe, S., Stolley, J. M., Nelson, C. E., Davis, R. L., Manlove, L. S., Pennell, C. A., Blazar, B. R., Chen, C. C., Geller, M. A., Vezys, V., & Masopust, D. Nat Commun. 2019;10(1):567.
Cutting Edge: Evidence for Nonvascular Route of Visceral Organ Immunosurveillance by T Cells
Steinert, E. M., Thompson, E. A., Beura, L. K., Adam, O. A., Mitchell, J. S., Guo, M., Breed, E. R., Sjaastad, F. V., Vezys, V., & Masopust, D. J Immunol. 2018;201(2):337-342.
T Cells in Nonlymphoid Tissues Give Rise to Lymph-Node-Resident Memory T Cells
Beura, L. K., Wijeyesinghe, S., Thompson, E. A., Macchietto, M. G., Rosato, P. C., Pierson, M. J., Schenkel, J. M., Mitchell, J. S., Vezys, V., Fife, B. T., Shen, S., & Masopust, D Immunity. 2018;48(2):327-338.e5.
Intravital mucosal imaging of CD8 + resident memory T cells shows tissue-autonomous recall responses that amplify secondary memory
Beura, L. K., Mitchell, J. S., Thompson, E. A., Schenkel, J. M., Mohammed, J., Wijeyesinghe, S., Fonseca, R., Burbach, B. J., Hickman, H. D., Vezys, V., Fife, B. T., & Masopust, D. Nat Immunol. 2018;19(2):173-182.
Normalizing the environment recapitulates adult human immune traits in laboratory mice
Beura, L. K., Hamilton, S. E., Bi, K., Schenkel, J. M., Odumade, O. A., Casey, K. A., Thompson, E. A., Fraser, K. A., Rosato, P. C., Filali-Mouhim, A., Sekaly, R. P., Jenkins, M. K., Vezys, V., Haining, W. N., Jameson, S. C., & Masopust, D. Nature. 2016;532(7600): 512-516.
IL-15-Independent Maintenance of Tissue-Resident and Boosted Effector Memory CD8 T Cells
Schenkel, J. M., Fraser, K. A., Casey, K. A., Beura, L. K., Pauken, K. E., Vezys, V., & Masopust, D. J Immunol. 2016;196(9): 3920-3926.
Quantifying Memory CD8 T Cells Reveals Regionalization of Immunosurveillance
Steinert, E. M., Schenkel, J. M., Fraser, K. A., Beura, L. K., Manlove, L. S., Igyártó, B. Z., Southern, P. J., & Masopust, D. Cell. 2015;161(4):737-749.
Lymphocytic choriomeningitis virus persistence promotes effector-like memory differentiation and enhances mucosal T cell distribution
Beura, L. K., Anderson, K. G., Schenkel, J. M., Locquiao, J. J., Fraser, K. A., Vezys, V., Pepper, M., & Masopust, D. J Leukoc Biol. 2015;97(2):217-225.
T cell memory. Resident memory CD8 T cells trigger protective innate and adaptive immune responses
Schenkel, J. M., Fraser, K. A., Beura, L. K., Pauken, K. E., Vezys, V., & Masopust, D. Science. 2014;346(6205):98-101.
Cutting edge: resident memory CD8 T cells occupy frontline niches in secondary lymphoid organs
Schenkel, J. M., Fraser, K. A., & Masopust, D. J Immunol. 2014;192(7):2961-2964.
Intravascular staining for discrimination of vascular and tissue leukocytes
Anderson, K. G., Mayer-Barber, K., Sung, H., Beura, L., James, B. R., Taylor, J. J., Qunaj, L., Griffith, T. S., Vezys, V., Barber, D. L., & Masopust, D. Nat Protoc. 2014;9(1):209-222.
Preexisting high frequencies of memory CD8+ T cells favor rapid memory differentiation and preservation of proliferative potential upon boosting
Fraser, K. A., Schenkel, J. M., Jameson, S. C., Vezys, V., & Masopust, D. Immunity. 2013;39(1):171-183.
Sensing and alarm function of resident memory CD8⁺ T cells
Schenkel, J. M., Fraser, K. A., Vezys, V., & Masopust, D. Nat Immunol. 2013;14(5):509-513.
Cutting edge: intravascular staining redefines lung CD8 T cell responses
Anderson, K. G., Sung, H., Skon, C. N., Lefrancois, L., Deisinger, A., Vezys, V., & Masopust, D. J Immunol. 2012;189(6):2702-2706.
Antigen-independent differentiation and maintenance of effector-like resident memory T cells in tissues
Casey, K. A., Fraser, K. A., Schenkel, J. M., Moran, A., Abt, M. C., Beura, L. K., Lucas, P. J., Artis, D., Wherry, E. J., Hogquist, K., Vezys, V., & Masopust, D. J Immunol. 2012;188(10):4866-4875.
Dynamic T cell migration program provides resident memory within intestinal epithelium
Masopust, D., Choo, D., Vezys, V., Wherry, E. J., Duraiswamy, J., Akondy, R., Wang, J., Casey, K. A., Barber, D. L., Kawamura, K. S., Fraser, K. A., Webby, R. J., Brinkmann, V., Butcher, E. C., Newell, K. A., & Ahmed, R. J Exp Med. 2010;207(3):553-564.
Memory CD8 T-cell compartment grows in size with immunological experience
Vezys, V., Yates, A., Casey, K. A., Lanier, G., Ahmed, R., Antia, R., & Masopust, D. Nature. 2009;457(7226):196-199.
Stimulation history dictates memory CD8 T cell phenotype: implications for prime-boost vaccination
Masopust, D., Ha, S. J., Vezys, V., & Ahmed, R. J Immunol. 2006;177(2):831-839.
Cutting edge: gut microenvironment promotes differentiation of a unique memory CD8 T cell population
Masopust, D., Vezys, V., Wherry, E. J., Barber, D. L., & Ahmed, R. J Immunol. 2006;176(4):2079-2083.
Activated primary and memory CD8 T cells migrate to nonlymphoid tissues regardless of site of activation or tissue of origin
Masopust, D., Vezys, V., Usherwood, E. J., Cauley, L. S., Olson, S., Marzo, A. L., Ward, R. L., Woodland, D. L., & Lefrançois, L. J Immunol. 2004;172(8):4875-4882.
Preferential localization of effector memory cells in nonlymphoid tissue
Masopust, D., Vezys, V., Marzo, A. L., & Lefrançois, L. Science. 2001;291(5512):2413-2417.
Direct analysis of the dynamics of the intestinal mucosa CD8 T cell response to systemic virus infection
Masopust, D., Jiang, J., Shen, H., & Lefrançois, L. J Immunol. 2001;166(4):2348-2356.
A critical role for CD40-CD40 ligand interactions in amplification of the mucosal CD8 T cell response
Lefrançois, L., Olson, S., & Masopust, D. J Exp Med. 1999;190(9):1275-1284.