Masopust Lab

PubMed Link (see below for selected publications)


CD4+ resident memory T cells dominate immunosurveillance and orchestrate local recall responses.

Beura LK, Fares-Frederickson NJ, Steinert EM, Scott MC, Thompson EA, Fraser KA, Schenkel JM, Vezys V, Masopust D. J Exp Med. 2019 Mar 28. DOI: 10.1084/jem.20181365


Virus-specific memory T cells populate tumors and can be repurposed for tumor immunotherapy.

Rosato PC, Wijeyesinghe S, Stolley JM, Nelson CE, Davis RL, Manlove LS, Pennell CA, Blazar BR, Chen CC, Geller MA, Vezys V, Masopust D. Nat Commun. 2019 Feb 4;10(1):567. 


Cutting Edge: Evidence for Nonvascular Route of Visceral Organ Immunosurveillance by T Cells.

Steinert EM, Thompson EA, Beura LK, Adam OA, Mitchell JS, Guo M, Breed ER, Sjaastad FV, Vezys V, Masopust D. J Immunol. 2018 Jul 15;201(2):337-342.


T Cells in Nonlymphoid Tissues Give Rise to Lymph-Node-Resident Memory T Cells. 

Beura LK, Wijeyesinghe S, Thompson EA, Macchietto MG, Rosato PC, Pierson MJ, Schenkel JM, Mitchell JS, Vezys V, Fife BT, Shen S, Masopust D. Immunity. 2018 Feb 20;48(2):327-338.e5.


Intravital mucosal imaging of resident memory CD8+ T cell shows tissue-autonomous recall responses that amplify secondary memory. 

Beura LK, Mitchell JS, Thompson EA, Schenkel JM, Mohammed J, Wijeyesinghe S, Fonseca R, Burbach BJ, Hickman HD, Vezys V, Fife BT, Masopust D. Nat Immunol. 2018 Feb;19(2):173-182


IL-15 independent maintenance of tissue resident and boosted effector memory CD8 T cells. 

Schenkel JM, Fraser KA, Casey KA, Beura LK, Pauken KE, Vezys V, Masopust D. 2016. J Immunol. 196:3920-6.


Normalizing the environment recapitulates adult human immune traits in laboratory mice. 

Beura LK, Hamilton SE, Bi K, Schenkel JM, Odumade OA, Casey KA, Thompson EA, Fraser KA, Rosato PC, Filali-Mouhim A, Sekaly RP, Jenkins MK, Vezys V, Haining WN, Jameson SC, Masopust D. 2016. Nature. 532:512-6.


Quantifying memory CD8 T cells reveals regionalization of immunosurveillance. 

Steinert EM, Schenkel JM, Fraser KA, Beura LK, Manlove LS, Igyarto BZ, Southern P, Masopust D. 2015. Cell. 161:737-49.


Resident memory CD8 T cells trigger protective innate and adaptive immune responses.

Schenkel JM, Fraser KA, Beura LK, Pauken KE, Vezys V, Masopust D. Science. 2014 Oct 3;346(6205):98-101.


Cutting Edge: Resident memory CD8 T cells occupy frontline niches in secondary lymphoid organs. 

Schenkel JS, Fraser KF, Masopust D. 2014. J Immunol. 192:2961-4.


Intravascular staining for discrimination of vascular and tissue leukocytes.

Anderson KG, Mayer-Barber K, Sung H, Beura L, James BR, Taylor JJ, Qunaj L, Griffith TS, Vezys V, Barber DL, Masopust D. Nat Protoc. 2014 Jan;9(1):209-22. 


Preexisting high frequencies of memory CD8+ T cells favor rapid memory differentiation and preservation of proliferative potential upon boosting. 

Fraser KA, Schenkel JM, Jameson SC, Vezys V, Masopust D. 2013. Immunity. 39:171-83.


Sensing and alarm function of resident memory CD8+ T cells. 

Schenkel, JM, Fraser KA, Vezys V, Masopust D. 2013. Nature Immunology. 14:509-13.


Cutting Edge: Intravascular staining redefines lung CD8 T cell responses. 

Anderson KG, Sung H, Skon CN, Lefrancois L, Deisinger A, Vezys V, Masopust D. 2012. J Immunol. 189:2702-6.


Antigen independent differentiation and maintenance of effector-like resident memory T cells in tissues. 

Casey KA, Fraser KA, Schenkel JM, Moran A, Abt MC, Beura LK, Lucas PJ, Artis D, Wherry EJ, Hogquist K, Vezys V, Masopust D. 2012. J Immunol. 188:4866-75.


Dynamic T cell migration program establishes resident memory within intestinal epithelium. 

Masopust D, Choo D, Vezys V, Wherry EJ, Duraiswamy J, Akondy RS, Wang J, Casey KA, Barber DL, Fraser KA, Kawamura KS, Webby RJ, Brinkmann V, Butcher EC, Newell KA, Ahmed R. 2010. J Exp Med, 207:553-64.


Memory CD8 T-cell compartment grows in size with immunological experience.

Vezys V, Yates A, Casey KA, Lanier G, Ahmed R, Antia R, Masopust D. Nature. 2009 Jan 8;457(7226):196-9.


Preferential localization of effector memory cells in nonlymphoid tissue. 

Masopust D, Vezys V, Marzo AL, Lefrancois L. 2001. Science. 291:2413-7.